CRT-Acervo - Resultado página 1

Base de dados :	CRT-Acervo
Pesquisa :	CITOMEGALOVIRUS/ISOL [Descritor de assunto]
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CRT-Acervo

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Id:	3344
Autor:	Viso, Ana T Rodriguez; Oliveira, Augusto C. Penalva de; Boas, Lucy S Vilas.
Título:	Cytomegalovirus Glycoprotein B Genotypes and Central Nervous System Disease in AIDS Patients.
Fonte:	J Med Virol;71(3):404-407, Nov. 2003. tab.
Resumo:	To investigate any association between cytomegalovirus glycoprotein B (CMV gB) subtypes and central nervous system (CNS) disease in AIDS patients, proportions of different gB genotypes detected in AIDS patients with CNS disease were compared with the gB genotypes detected in AIDS patients with no neurological disorder. The patients were matched by CD4+ cell counts. CMV was detected by PCR in cerebrospinal fluid (CSF) samples obtained from AIDS patients with CNS disease and from urine and saliva samples obtained from AIDS patients without CNS disease. CMV strains obtained were digested by restriction enzymes HinffI and RsaI to classify the genotypes. The CMV gB genotype was determined in 26 CSF samples. Of these, 11/26 (42.3 por cento) typed as gB group 1, seven (26.9 por cento) as gB2, four (15.4 por cento) as gB3, and four (15.4 por cento) as gB4. The CMV gB genotype frequency distribution in the 42 AIDS patients without CNS disease showed that 18/42 (42.8 por cento) were classified as gB group 1, 10 (23.8 por cento) as gB2, seven (16.6 por cento) as gB3, and seven (16.6 por cento) as gB4. In the present study, no association was found between CMV gB genotypes and CMV-related central nervous system disease.
Descritores:	Infecções Oportunistas Relacionadas com a AIDS/fisiopatol Infecções Oportunistas Relacionadas com a AIDS/virol Contagem de Linfócito CD4 Infecções do Sistema Nervoso Central/fisiopatol Infecções do Sistema Nervoso Central/virol Citomegalovirus/clas Citomegalovirus/genet Citomegalovirus/isol Citomegalovirus/patogen DNA Viral/lcr Genótipo Infecções por HIV/compl Infecções por HIV/virol Reação em Cadeia da Polimerase Proteína de Invólucro Viral/genet
Limites:	Humano
Meio Eletrônico:	http://www3.crt.saude.sp.gov.br/arquivos/arquivos_...
Localização:	BR1310.1; Formato Eletrônico

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CRT-Acervo

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Id:	3336
Autor:	Bueno, Stella M H S; Pannuti, Claudio S; Muccioli, Cristina.
Título:	Cytomegalovirus Antigenemia in Acquired Immunodeficiency Syndrome Patients With Untreated Cytomegalovirus Retinitis.
Fonte:	Am J Ophthalmol;122(6):847-852, Dec. 1996. .
Resumo:	PURPOSE: To determine the frequency of cytomegalovirus (CMV) viremia in patients with acquired immunodeficiency syndrome (AIDS) and untreated CMV retinitis using conventional cell culture isolation and the sensitive CMV antigenemia assay. METHODS: We examined 24 AIDS patients with ophthalmologic diagnosis of untreated CMV retinitis and 24 AIDS patients without present or past retinitis (control patients) from three medical centers between September 1992 and March 1994. Cytomegalovirus antigenemia was detected by an indirect peroxidase staining in 300,000 cytocentrifuged neutrophils, using a mixture of murine monoclonal antibodies directed against the pp65 lower matrix protein of CMV. RESULTS: Positive antigenemia was demonstrated in eight (33.3 por cento) of the 24 retinitis patients and in none of the 24 control patients (P < .001). Only two of the eight antigenemia-positive patients had a concurrent positive CMV isolation from blood leukocytes by conventional cell culture assay. CONCLUSIONS: These results emphasize the risk of extraocular disease in AIDS patients with CMV retinitis because the virus is often present in peripheral blood leukocytes. The CMV antigenemia assay may be a simple and rapid means of identifying those patients with unilateral retinitis at highest risk of developing CMV retinitis of the fellow eye or of visceral CMV disease if intravitreal injections or implants are used as sole treatment for CMV retinitis.
Descritores:	Infecções Oportunistas Relacionadas com a AIDS/diag Infecções Oportunistas Relacionadas com a AIDS/quimioter Anticorpos Monoclonais Anticorpos Antivirais/imunol Antígenos de Vírus/anal Antivirais/uso terap Separação Celular Células Cultivadas Citomegalovirus/imunol Citomegalovirus/isol Retinite por Citomegalovirus/diag Retinite por Citomegalovirus/quimioter Ganciclovir/uso terap Técnicas Imunoenzimáticas Neutrófilos/citol Neutrófilos/virol Viremia/diag Viremia/quimioter
Limites:	Humano Masculino Feminino Adulto
Localização:	BR1310.1

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